PharmaTools.AI — Nick Lamb · AI Research & Engineering

Evaluation, verification and oversight for autonomous AI systems.

AI agents are starting to do real work — and mostly, we take their word for it. I design experiments that reveal how these systems actually behave, and build open-source tools that check their answers against evidence.

agents & multi-agent systems·evaluation·evidence & verification·privacy·healthcare AI

Explore Observer Zero Research & publications GitHub

Nick Lamb, PhD, CMPPIndependent AI researcher & engineer · 20+ years in regulated medical communications

01Flagship research · Observer Zero

What happens when AI agents become scientists — inside a world whose ground truth we control?

Observer Zero is a persistent artificial society for studying how autonomous LLM agents gather evidence, interpret it, revise their beliefs and reach collective conclusions. Its agents inhabit Meridian — a world with fictional physics — where they run experiments, exchange letters and hold explicit, probabilistic beliefs about laws they cannot see. Because the simulator holds perfect ground truth, every belief can be scored against reality: the design separates what a society had the evidence to know from what it actually came to believe.

When the laws of their world secretly changed, the agents gathered evidence enough for a blind statistical detector to find the change — and almost none of them ever believed it.

235seeded simulated universes across two studies

40 / 40eight-agent runs where a detector, fed only the agents’ own measurements, found the hidden change

1 / 276agents concluded that a physical law of their world had changed

6,880 / 0agent-days of opportunity in homogeneous grounded societies — and zero voluntary letters

Eight agents measure a world they can never see into directly. Observer Zero sits outside it, holding the ground truth — so what each agent could know can be separated from what it came to believe.

STUDY 01Complete

When the Laws Changed

Can autonomous agents recognise that a physical law of their world has changed?

Across 150 universes, 90–100% of agents transiently noticed something was wrong — yet 0 of 40 gravity-shift worlds reached a strict law-change conclusion. The anomalies were real; the interpretation reached for faulty instruments instead.

STUDY 02Complete · under review at JASSS

Does Society Help?

Can an artificial scientific society overcome the individual failure through social interaction?

Pre-registered, 85 universes, societies of two and eight. Left alone, grounded societies never spoke; seeding one communicative agent spread unsupported claims, not scrutiny. The combined two-study paper is under review at JASSS, with the model published in the CoMSES library.

STUDY 03Next · in design

The Simulation Question

What would it take for an AI scientist to discover that its world is simulated?

The next study, now being designed, targets world-model revision: when does an intelligent system stop assimilating anomalous evidence into its existing explanation and conclude that the explanatory model itself is inadequate?

Explore Observer Zero Read the preprint

02Selected systems

From research questions to working systems.

Strong claims about AI behaviour need trustworthy measurement. One question runs through all three of these systems — how do we know an AI is doing what we think it is? — and each answers it in a different domain. Every one ships with its own evaluation.

Evaluation & verification · open source

OpenGATE

Can an AI claim prove where it came from?

An open-source verification framework for evidence-grounded AI. Deterministic grounding and extraction checks — no LLM judge anywhere in the loop — so verdicts are reproducible, auditable, and cheap enough to run on every answer or every commit. Four production systems run on it in CI, where it has caught silent parse failures, a citation-parser inconsistency, and a simplifier dropping an antibiotic dose from a discharge summary.

npm · 1.9K downloads/moPyPIMCP serverGitHub Action

Explore OpenGATE →Read the paper →

Privacy infrastructure · Anthropic MCP Directory

Redacta

How can agents work with sensitive information without exposing it unnecessarily?

A privacy boundary for AI and agent workflows. Redacta pseudonymises patient identifiers — names, NHS numbers, dates — into labelled tokens, and its MCP server keeps the map that reverses them outside the model’s context entirely. It then checks the model’s output for identifiers that found their way back in, so the boundary is verified rather than assumed. Benchmarked under adversarial attack by its own published evaluation harness, and deployable from a free iPhone app to a self-hosted Kubernetes cluster.

MCP serverSelf-hostediPhone appAdversarially benchmarked

Explore Redacta →See the Gauntlet →

Production healthcare AI · MHRA Class I device

Patiently AI

Can generative AI simplify medical information without losing meaning?

A deployed, MHRA-registered Class I medical device that turns clinical letters, results and discharge summaries into plain language — in 18 languages, on web, iOS and Android. Validated in a three-phase study — computational readability analysis, expert review by 15 healthcare professionals who rated outputs 4.49/5 for accuracy, and a 54-patient survey. Five national awards, in real-world use.

MHRA Class I18 languagesValidation study5 national awards

Explore Patiently AI →

03The wider lab

Experiments, tools and detours.

The same method at smaller scale: build it, measure it, publish the measurement. A progression runs through the lab — from applications, to infrastructure, to evaluation, to studying the behaviour of the systems themselves.

→Verification

RefCheckr

Automated claim and reference verification for medical and scientific content — with its model choices benchmarked in the open.

→Infrastructure

Groundwork

Deployment-readiness harnesses for document QA and structured extraction — a CI gate that catches fabrication before users see it.

→Retrieval · MCP Directory

PubCrawl

Real literature for AI assistants: PubMed, Europe PMC, clinical trials and drug labels over MCP — no hallucinated citations.

→Compliance

MedCheckr®

Checks promotional claims against 11 national and international pharma codes of practice, with citation-grounded feedback.

→Fine-tuning · validation

Time-Machine Chess

Era-specific engines fine-tuned on 150 years of historical games — and validated against the history they learned from.

→Labs

All experiments

HushMap, PosterLens, StudyDiff, BiomarkerFinder, TrialGen, PlaceboGPT and other prototypes and detours live in the Labs.

04About

Who’s behind this.

I build AI systems — then ask harder questions about whether we should trust them.

Nick Lamb is an independent AI researcher and engineer with an unusual route in: twenty years of regulated medical communications (PhD, CMPP), a field where every claim must trace to evidence. That standard now runs through everything on this page — agents whose beliefs are scored against hidden ground truth, verification that never takes a model’s word for it, and a registered medical device validated before it reached patients.

PharmaTools.AI began as a collection of healthcare AI tools, and healthcare remains its proving ground: few domains punish an ungrounded claim faster. The work now spans empirical AI research, autonomous agents, evaluation and privacy infrastructure — much of it open source.

Research & publications → GitHub ↗ Consulting → Contact →

Nick Lamb, PhD, CMPPAlso available for hands-on advisory in pharma, medtech and healthcare AI.

✓ VerifiableMHRA Class IRegistered medical device (Patiently AI) ✓ VerifiableUnder review · JASSSCombined Observer Zero paper; model on CoMSES ✓ VerifiableAnthropic Directory ×2Redacta & PubCrawl, listed in the official MCP directory ✓ Verifiable3,000+ / monthDownloads across the open-source suite (npm · PyPI)

Interested in the same questions?

How autonomous AI systems reason, use evidence — and fail. If you’re working on related problems, or want this kind of discipline applied to your own AI systems, I’d be glad to hear from you.

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